Sep 2011

Dramatic Improvement of Facial Angiofibromas in Tuberous Sclerosis With Topical Rapamycin: Optimizing a Treatment Protocol

Author Affiliations

Author Affiliations: Division of Dermatology, Department of Medicine, Georgetown University Hospital (Drs DeKlotz, Ogram, Singh, Dronovalli, and MacGregor), Washington, DC; Departments of Dermatology (Drs DeKlotz, Ogram, Singh, and Dronovalli) and Medicine(Drs DeKlotz and Dronovalli), Washington Hospital Center, Washington, DC.

Arch Dermatol. 2011;147(9):1117-1118. doi:10.1001/archdermatol.2011.254

In a recent report on the use of topical rapamycin to treat facial angiofibromas, Haemel et al1 demonstrated the efficacy of rapamycin tablets mixed in petrolatum, 1%, ointment. Based on these findings and another report of topical rapamycin solution compounded with Eucerin (Eucerin, Hamburg, Germany),2 we proceeded with a similar approach in our patient with tuberous sclerosis complex (TSC).

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