Author Affiliations: Division of Dermatology, Department of Medicine, Georgetown University Hospital (Drs DeKlotz, Ogram, Singh, Dronovalli, and MacGregor), Washington, DC; Departments of Dermatology (Drs DeKlotz, Ogram, Singh, and Dronovalli) and Medicine(Drs DeKlotz and Dronovalli), Washington Hospital Center, Washington, DC.
In a recent report on the use of topical rapamycin to treat facial angiofibromas, Haemel et al1 demonstrated the efficacy of rapamycin tablets mixed in petrolatum, 1%, ointment. Based on these findings and another report of topical rapamycin solution compounded with Eucerin (Eucerin, Hamburg, Germany),2 we proceeded with a similar approach in our patient with tuberous sclerosis complex (TSC).
DeKlotz CMC, Ogram AE, Singh S, Dronavalli S, MacGregor JL. Dramatic Improvement of Facial Angiofibromas in Tuberous Sclerosis With Topical Rapamycin: Optimizing a Treatment Protocol. Arch Dermatol. 2011;147(9):1117-1118. doi:10.1001/archdermatol.2011.254