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Sep 2011

Congestive Heart Failure in a Patient With Cutaneous T-Cell Lymphoma Treated With Low-Dose Interferon Alfa-2b

Author Affiliations

Author Affiliations: Department of Dermatology (Drs Evans, Rook, and Kim) and Department of Medicine, Divisions of Hematology/Oncology (Dr Loren) and Cardiovascular Medicine (Dr Glassberg), The Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Arch Dermatol. 2011;147(9):1123-1124. doi:10.1001/archdermatol.2011.246

Interferons are natural polypeptides used as biologic therapy in patients with cutaneous T-cell lymphoma (CTCL), melanoma, and hepatitis C. In CTCL, interferon alfa enhances the host's cytotoxic T-cell response through upregulation of CD8+ and natural killer cell activity and downregulation of the helper T cell type 2 cytokine profile.1,2

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