Oct 2011

A Case of Adult-Onset Asthma With Periocular Xanthogranulomas

Author Affiliations

Author Affiliations: University of Pennsylvania School of Medicine (Ms Agi), Departments of Dermatology (Drs Gober, Ferenczi, and Rosenbach) and Allergy and Immunology (Dr Takach), Hospital of the University of Pennsylvania, Wills Eye Institute (Dr Eagle), and Department of Pathology, Thomas Jefferson University (Dr Eagle), Philadelphia, Pennsylvania.

Arch Dermatol. 2011;147(10):1230-1231. doi:10.1001/archdermatol.2011.279

We report a case of adult-onset asthma with periocular xanthogranuloma (AAPOX), a rare syndrome that falls into the general clinical category of periocular adult xanthogranulomatous diseases such as necrobiotic xanthogranuloma and Erdheim-Chester disease. Adult-onset asthma with periocular xanthogranuloma is a distinct entity within this group, which, to our knowledge, has not been previously described in the dermatology literature and may be an underrecognized entity.

A 55-year-old African American man presented with a 35-year history of indurated periorbital nodules associated with mild periocular pruritus. One year after the onset of periorbital induration, he developed asthma, which was confirmed by the results of pulmonary function testing and was well controlled with inhalers. He denied a history of chronic rhinosinusitis.

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