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Dec 2011

A Vesiculobullous Eruption in a Hospitalized Patient —Diagnosis

Author Affiliations
 

SECTION EDITOR: MARY S. STONE, MD; ASSISTANT SECTION EDITORS: SOON BAHRAMI, MD; CARRIE ANN R. CUSACK, MD; SENAIT W. DYSON, MD; MOLLY A. HINSHAW, MD; ARNI K. KRISTJANSSON, MD

Arch Dermatol. 2011;147(12):1443-1448. doi:10.1001/archderm.147.12.1443-g

Findings from a lesional biopsy showed a subepidermal vesicle formation with neutrophils, eosinophils, and fibrin in the vesicle. In addition, a superficial and middermal perivascular infiltrate with eosinophils was present. The perilesional biopsy showed linear staining for IgA at the dermoepidermal junction (DEJ), with no notable deposition of IgG, IgM, or C3. By the time the dermatology department was consulted, the vancomycin and combination piperacillin sodium and tazobactam sodium had been stopped, and the patient was already showing improvement. She was treated with topical triamcinolone acetonide ointment, and her lesions fully resolved within 10 days.

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