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Jan 2012

Blistering Mucosal Eruption in a Young Woman With Systemic Lupus Erythematosus —Diagnosis

Author Affiliations
 

SECTION EDITOR: MARY S. STONE, MD; ASSISTANT SECTION EDITORS: SOON BAHRAMI, MD; CARRIE ANN R. CUSACK, MD; SENAIT W. DYSON, MD; MOLLY A. HINSHAW, MD; ARNI K. KRISTJANSSON, MD

Arch Dermatol. 2012;148(1):113-118. doi:10.1001/archderm.148.1.114-a

Histopathologic examination of a biopsy specimen showed interface mucositis with lymphocytes attacking the mucosal-submucosal junction associated with vacuolar change of the basal layer and scattered apoptotic keratinocytes (Figure 2). Cleft formation was observed between the mucosa and submucosa with hemorrhage present within the vesicle (Figure 3). Direct immunofluorescence microscopy demonstrated moderate to strong staining for IgG and C3 and discontinuous, weak staining for IgA and IgM along the mucosal-submucosal junction.

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