Author Affiliation: Department of Dermatology, College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona.
In this issue, Wu et al1 report a 79.3% prevalence of dyslipidemia (DLP) among adults with granuloma annulare (GA) compared with a 51.9% prevalence of DLP in controls matched for age, sex, race/ethnicity, and presence of type 2 diabetes mellitus, hypothyroidism, and hypertension (P < .001). Although the cause of GA is unknown,2 the finding of DLP among so many patients comes as a surprise. Heretofore, only vague hints suggested a possible association with a lipid abnormality. Patients with generalized GA occasionally have an abnormality of glucose metabolism, microangiopathy, and microdroplet lipid deposits inside histiocytes.
Dahl MV. Testing Lipid Levels in Granuloma AnnulareComment on “Dyslipidemia in Granuloma Annulare”. Arch Dermatol. 2012;148(10):1136-1137. doi:10.1001/archdermatol.2012.1503