[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.197.142.219. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Evidence-Based Dermatology: Review
ONLINE FIRST
Nov 2012

Measurement Properties of Outcome Measures for VitiligoA Systematic Review

Author Affiliations
 

SECTION EDITOR: MICHAEL BIGBY, MD; ASSISTANT SECTION EDITORS: OLIVIER CHOSIDOW, MD, PhD; ROBERT P. DELLAVALLE, MD, PhD, MSPH; DAIHUNG DO, MD; URBÀ GONZÁLEZ, MD, PhD; CATALIN M. POPESCU, MD, PhD; HYWEL WILLIAMS, MSc, PhD, FRCP

Author Affiliations: Department of Dermatology and Netherlands Institute for Pigment Disorders (Drs Vrijman, Linthorst Homan, van der Veen, Wolkerstorfer, and Spuls), Medical Library and Dutch Cochrane Center (Dr Limpens), Academic Medical Center, University of Amsterdam; The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (Dr van der Veen); Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre (Dr Terwee); and Department of Dermatology, Onze Lieve Vrouwe Gasthuis (Dr Vrijman); Amsterdam, the Netherlands.

Arch Dermatol. 2012;148(11):1302-1309. doi:10.1001/archdermatol.2012.3065
Abstract

Objective To summarize and critically appraise the evidence on the measurement properties of clinician-, patient-, and observer-reported outcomes, measuring any construct of interest in patients with all types of vitiligo.

Data Sources Electronic databases including PubMed (1948 to July 2011), OVID EMBASE (1980 to July 2011), and CINAHL (EBSCOhost) (1982 to July 2011) were searched.

Study Selection Two authors independently screened all records for eligibility. For inclusion, the study population had to include patients with vitiligo, for which outcome measures were developed or evaluated on their measurement properties. The initial search retrieved 1249 records, of which 14 articles met the inclusion criteria.

Data Extraction Characteristics of the included instruments, study population, and results of the measurement properties were extracted. The Consensus-Based Standards for the Selection of Health Status Measurement Instruments (COSMIN) 4-point checklist, combined with quality criteria for measurement properties, was used to calculate the overall level of evidence per measurement property of each instrument. Independent extraction and assessment was performed by 2 authors.

Data Synthesis Eleven different measurement instruments were identified. Strong evidence was found for a positive internal consistency of the Dermatology Life Quality Index. For other instruments, the evidence of measurement properties was limited or unknown.

Conclusions Recommendations on the use of specific outcome measures for vitiligo should be formulated with caution because current evidence is insufficient owing to a low number of studies with poor methodological quality and unclear clinical relevance. To recommend outcome measures for vitiligo, further research on measurement properties of clinical relevant outcome measures for vitiligo according to COSMIN quality criteria is needed.

×