[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.159.202.12. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 189
Citations 0
Off-Center Fold
Nov 2012

Fleshy Papules in Areas of Friction in a Man With Endocrine Neoplasms—Diagnosis

Author Affiliations
 

SECTION EDITOR: MARY S. STONE, MD; ASSISTANT SECTION EDITORS: SOON BAHRAMI, MD; CARRIE ANN R. CUSACK, MD; MOLLY A. HINSHAW, MD; ARNI K. KRISTJANSSON, MD; LORI D. PROK, MD;

Arch Dermatol. 2012;148(11):1318. doi:10.1001/archderm.148.11.1318-a

Histologic evaluation of biopsy specimens from both the neck and the abdomen demonstrated an expansile dermis composed of thick whorls of collagen bundles consistent with collagenomas (Figure 3). The presence of cutaneous collagenomas and multiple endocrine neoplasms is most consistent with MEN1. Subsequent genetic analysis of MEN1 was positive for a heterozygous deletion (c.1670-1672delAGA) known to be associated with MEN1. Our patient underwent resection of all 4 parathyroid glands, and distal pancreatectomy is pending. Also, he will follow standard MEN1 screening guidelines for other neoplasms.1 Genetic testing of his asymptomatic family members, including his children, is also pending, as screening for MEN1 begins at the age of 5 years.

First Page Preview View Large
First page PDF preview
First page PDF preview
×