Author Affiliations: Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.
Phymas are benign tumors of the face caused by hypertrophy of sebaceous glands and connective tissue. They are pathognomonic for rosacea, a common centrofacial inflammatory dermatosis of unknown origin. In spite of various factors that have been implicated in its etiopathology, including genetic susceptibility, vascular disturbances, dysregulation of the innate immune response, dermal matrix degeneration, actinic damage, and microbial organisms, the exact pathogenesis of rosacea and its different clinical manifestations remains unknown.
Voth H, Wenzel J, Bieber T, Landsberg J. Phymatous Transformation of Facial Cutaneous Vascular Malformations: Clues to Phyma Pathogenesis. JAMA Dermatol. 2013;149(3):368-369. doi:10.1001/jamadermatol.2013.1213