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Mar 2013

Hair-Shaft Abnormality in a 7-Year-Old Girl—Quiz Case

Author Affiliations
 

SECTION EDITOR: MARY S. STONE, MD; ASSISTANT SECTION EDITORS: SOON BAHRAMI, MD; CARRIE ANN R. CUSACK, MD; MOLLY A. HINSHAW, MD; ARNI K. KRISTJANSSON, MD; LORI D. PROK, MD

JAMA Dermatol. 2013;149(3):358-363. doi:10.1001/jamadermatol.2013.1490a

A 7-year-old girl presented with complaints of hair loss and a known partial biotinidase deficiency since birth. Biotin supplementation was discontinued after the first year of life because clinical manifestations were absent, and laboratory findings were normal. At age 2 years, hair loss and eczema occurred. Owing to low biotinidase activity, biotin supplementation, 20 mg/wk, was restarted, but it was again discontinued at age 3 years because normal biotin levels had been achieved once more.

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