Author Affiliation: Department of Dermatology, Stanford University School of Medicine, Redwood City, California.
Vismodegib is useful to treat locally advanced or metastatic basal cell carcinomas (BCCs),1 but to our knowledge, its use as a neoadjuvant to shrink BCCs before surgery has not been reported. This case illustrates the role of vismodegib as a neoadjuvant agent. In addition, this case highlights the fact that a patient with Gorlin syndrome can develop resistant BCCs while taking vismodegib, a phenomenon not widely recognized although recently reported.2
Chang ALS, Atwood SX, Tartar DM, Oro AE. Surgical Excision After Neoadjuvant Therapy With Vismodegib for a Locally Advanced Basal Cell Carcinoma and Resistant Basal Carcinomas in Gorlin Syndrome. JAMA Dermatol. 2013;149(5):639-641. doi:10.1001/jamadermatol.2013.30