Author Affiliations: University of Texas Medical School at Houston (Dr Lester); Skin and Laser Surgery Associates, Pasadena, Texas (Dr Joseph).
Wound Seal (Biolife LLC) is a product composed of a hydrophilic polymer and potassium iron oxyacid salt that aids in hemostasis in wounds that are left to heal by secondary intention. We report a foreign-body reaction that results in the dermis following its use.
An 89-year-old white man had a 2.4 × 2.3-cm squamous cell carcinoma (SCC) excised from his left anterior lower leg via Mohs micrographic surgery. Owing to its large size and anatomic location, the defect was left to heal by secondary intention. Hemostasis was achieved with spot electrocoagulation followed by application of Wound Seal to the base of the wound. At his follow-up visit 4 months later, he was found to have a 1.5-cm pink nodule near the now well-healed scar from excision of the SCC, which was biopsied to confirm the diagnosis of SCC.
Lester LJ, Joseph AK. Foreign-Body Reaction to Wound Seal. JAMA Dermatol. 2013;149(5):632. doi:10.1001/jamadermatol.2013.2620