Morphea is an insidious disease with an unpredictable course and wide spectrum of clinical manifestations ranging from skin-limited plaques to linear morphea involving muscle or bone. There can be morbidity from cosmetic disfigurement, functional limb defects, or internal organ involvement. Studies have demonstrated the efficacy of methotrexate or UV-A1 phototherapy for severe disease; however, even after treatment or spontaneous remission, scars and other permanent disease sequelae remain.
Chiu YE. Evaluating the Clinical Utility of Autoantibodies in Morphea. JAMA Dermatol. 2013;149(10):1166. doi:10.1001/jamadermatol.2013.4908