[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.176.107. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Comment & Response
December 2013

IgG4-Related Skin Disease—Reply

Author Affiliations
  • 1Department of Dermatology, Henri Mondor Hospital, Créteil, France
  • 2Department of Pathology, Henri Mondor Hospital, Créteil, France
JAMA Dermatol. 2013;149(12):1440. doi:10.1001/jamadermatol.2013.7329

In Reply We read with interest the letter by Lehman et al about our 2 cases of IgG4-related disease (IgG4-RD) limited to the skin.1 In both cases, diagnosis of IgG4-RD was based on the presence of skin pseudolymphomatous nodules similar to those reported in previously published cases of cutaneous IgG4-RD2 and histologic features in accordance with the Comprehensive Diagnosis Criteria of the disease published in 20123 (ie, dense lymphocytic infiltrates occupying the dermis and the hypodermis, storiform fibrosis, and numerous polytypic plasma cells). Moreover, we showed that, more than 40% of plasma cells were IgG4+, and the ratio IgG4/IgG plasma cells was greater than 40% in both patients (76% in one and 100% in the other). Following all these criteria, our cases were indeed consistent with probable IgG4-RD.

First Page Preview View Large
First page PDF preview
First page PDF preview
×