A critical practice gap exists in identifying the causes of psoriasis flares, especially medication-related causes. Some physicians may not consistently examine medications for their contribution to psoriasis flares. However, a careful consideration of the role of medications in psoriasis exacerbation may improve long-term psoriasis control.
Several factors are important in evaluating the role of medications in psoriasis flares: (1) medications can exacerbate preexisting psoriasis and/or induce psoriasis on clinically uninvolved skin in patients with psoriasis (the incidence of psoriasis exacerbation is generally greater than that of psoriasis induction); (2) the strength of evidence linking different medications with psoriasis flares varies considerably; and (3) the latency period between drug ingestion and psoriasis flares varies among medications and can be much lengthier for certain medications.
Armstrong AW. Psoriasis Provoked or Exacerbated by MedicationsIdentifying Culprit Drugs . JAMA Dermatol. 2014;150(9):963. doi:10.1001/jamadermatol.2014.1019