Xeroderma pigmentosum (XP) is a group of rare autosomal recessive conditions characterized by defective DNA repair. Exposure to UV light gives rise to cutaneous neoplasms already in childhood. Since the underlying genetic defect can not yet be corrected, prophylactic measures are of utmost importance. Meticulous protection from sunlight and early excision of skin tumors are mandatory. Surgical removal of sun-damaged skin may prevent the development of neoplasms. Excising and resurfacing the skin using grafts obtained from sun-protected regions has sometimes been performed.1- 4 Although the benefit of dermabrasion is well documented in patients with actinic damage,5,6 there are only a few reports on this approach in XP.4,7- 9 We report a case of XP with a well-controlled long-term result obtained by dermabrasion and documented both clinically and histopathologically.
König A, Friederich HC, Hoffmann R, Happle R. Dermabrasion for the Treatment of Xeroderma Pigmentosum. Arch Dermatol. 1998;134(2):241-242. doi: