A deep excisional biopsy specimen was obtained from a nodular lesion. Macroscopically, yellowish white, creamy material was observed in the nodular mass. Microscopic examination with polarized light of the aspirate from the lesion showed long, needlelike crystals radially arranged in clusters. Histopathologic study of the biopsy specimen revealed that the lesion had the architectural pattern of a foreign body granuloma. Eosinophilic deposits of amorphous urate crystals were present in the central area, deep in the subcutaneous tissue. These aggregates were surrounded by a granulomatous infiltrate containing foreign body giant cells.
Panniculitis and Ulcers in a Young Man. Arch Dermatol. 1998;134(4):499-504. doi: