Systemic amyloidosis is a rare disorder with a poor prognosis that usually occurs in the elderly. Clinically, systemic amyloidosis could be classified as primary systemic amyloidosis, multiple myeloma-associated amyloidosis, secondary systemic amyloidosis, and heredofamilial amyloidosis.1,2 Since cardiac amyloidosis is the principal cause of death in primary systemic amyloidosis,3 early detection of cardiac involvement is an important issue. Although the combination of increased thickness of the ventricular wall (hypertrophy) with a low-voltage electrocardiographic pattern is highly specific for cardiac amyloidosis,4 systemic amyloidosis should be confirmed via a tissue biopsy to demonstrate amyloid deposits.
Huang C, Wang W, Wong C. Skin Biopsy Gives the Potential Benefit in the Diagnosis of Systemic Amyloidosis Associated With Cardiac Involvement. Arch Dermatol. 1998;134(5):643-645. doi: