June 1998

Human Herpesvirus 6 Infection in Patients With Exanthema After Allogeneic Bone Marrow Transplantation

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Dermatol. 1998;134(6):759-760. doi:

Frequent reactivation of human herpesvirus 6 (HHV-6) has been demonstrated in immunocompromised patients after renal or bone marrow transplantation (BMT). Using polymerase chain reaction (PCR), HHV-6 DNA has been detected in exanthematous skin after BMT,1 as well as in skin and/or rectal biopsy specimens of patients without exanthema prior to undergoing BMT.2 One study showed that after allogeneic BMT there is an increased risk of developing graft-vs-host disease, in which HHV-6 DNA is found in rectal and/or skin biopsy specimens.2 To investigate a pathogenic role of HHV-6 reactivation during cutaneous exanthema after allogeneic BMT, we determined HHV-6 DNA levels using quantitative PCR in blood and simultaneously in both erythematous and normal skin biopsy specimens.

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