Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998
Frequent reactivation of human herpesvirus 6 (HHV-6) has been demonstrated in immunocompromised patients after renal or bone marrow transplantation (BMT). Using polymerase chain reaction (PCR), HHV-6 DNA has been detected in exanthematous skin after BMT,1 as well as in skin and/or rectal biopsy specimens of patients without exanthema prior to undergoing BMT.2 One study showed that after allogeneic BMT there is an increased risk of developing graft-vs-host disease, in which HHV-6 DNA is found in rectal and/or skin biopsy specimens.2 To investigate a pathogenic role of HHV-6 reactivation during cutaneous exanthema after allogeneic BMT, we determined HHV-6 DNA levels using quantitative PCR in blood and simultaneously in both erythematous and normal skin biopsy specimens.
Le Cleach L, Joberty C, Fillet AM, Sutton L, Cordonnier C, Francès C, Agut H, Chosidow O. Human Herpesvirus 6 Infection in Patients With Exanthema After Allogeneic Bone Marrow Transplantation. Arch Dermatol. 1998;134(6):759-760. doi: