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June 1998

Hypopigmentation of the Extremities

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Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Dermatol. 1998;134(6):743-748. doi:

Hypopigmentation, which is a rare manifestation of sarcoidosis, was initially described by Maycock et al1 in 1963. Hypopigmented lesions may be the presenting sign of sarcoidosis.2,3 Clinically, the hypopigmented lesions may appear as macules, papules, or nodules. Skin biopsy findings can confirm a suspected diagnosis of sarcoidosis by demonstrating classic noncaseating dermal granulomas. In the previously reported cases, granulomas were rarely seen in macular lesions,24 but they were usually evident in biopsy specimens of nodular lesions. 2,57

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