Genetic changes that contribute to carcinogenesis include activation of oncogenes and inactivation of tumor suppressor genes.
Since the process of carcinogenesis is thought to occur as a stepwise accumulation of genetic alterations, it is important to select the precancerous lesions to detect an early event for the tumor formation. The study of premalignant lesions became feasible with a recent modified microdissection technique that allows the procurement of tissue from microscopic lesions for genetic analysis.
Böni R, Zhuang Z, Albuquerque A, Vortmeyer A, Duray P. Loss of Heterozygosity Detected on 1p and 9q in Microdissected Atypical Nevi. Arch Dermatol. 1998;134(7):882-883. doi: