July 1998

Loss of Heterozygosity Detected on 1p and 9q in Microdissected Atypical Nevi

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Dermatol. 1998;134(7):882-883. doi:

Genetic changes that contribute to carcinogenesis include activation of oncogenes and inactivation of tumor suppressor genes.

Since the process of carcinogenesis is thought to occur as a stepwise accumulation of genetic alterations, it is important to select the precancerous lesions to detect an early event for the tumor formation. The study of premalignant lesions became feasible with a recent modified microdissection technique that allows the procurement of tissue from microscopic lesions for genetic analysis.

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