July 1998

Efficacy of Low-Dose Isotretinoin in Patients With Treatment-Resistant Rosacea

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Dermatol. 1998;134(7):884-885. doi:

Isotretinoin was shown to be effective in patients with treatment-resistant rosacea by Nikolowski and Plewig1 in 1980 for the first time. Since then, many other studies24 confirmed its efficacy in a daily dose of 0.5 to 1.0 mg/kg. However, it has also been noted that adverse effects of the drug may limit its use. In this study, we aimed to determine if low doses of isotretinoin were effective in patients with treatment-resistant rosacea.

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