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August 1998

Congenital Langerhans Cell Histiocytosis: The Utility of the Tzanck Test as a Diagnostic Screening Tool

Arch Dermatol. 1998;134(8):1039-1040. doi:

Congenital Langerhans cell histiocytosis is a rare eruption with polymorphic manifestations that presents at birth or in the neonatal period. Patients may have single or multiple papules or nodules that usually involute spontaneously. A more generalized papular or vesicular form of the disorder is frequently mistaken for congenital varicella or herpes simplex infection. Previously considered self-healing, this term has been discarded by many dermatologists because the course is unpredictable, and a minority of affected children have a progressive or relapsing course.15 We report 2 cases of congenital Langerhans cell histiocytosis in which the diagnosis was initially suggested by findings noted on Tzanck tests of the cutaneous lesions.

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