A 31-year-old woman with human immunodeficiency virus (HIV) and a history of pulmonary tuberculosis and oral herpes simplex presented with a 7-month history of hyperkeratotic plaques on the soles of her feet. The plaques were mildly tender on weight bearing but were otherwise asymptomatic. No change in size or number of lesions had occurred in the preceding several months. No history of widespread eruption or similar lesions elsewhere on the body could be elicited during the initial patient interview. The patient had discontinued her suppressive acyclovir therapy 2 months before her evaluation and was taking no other medications.
Bitman LM, Rabinowitz AD. Hyperkeratotic Plantar Plaques in an HIV-Positive Patient. Arch Dermatol. 1998;134(8):1019-1024. doi: