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September 1998

No Evidence of HHV-8 Infection in Patients With Pemphigus Vulgaris/Foliaceus

Arch Dermatol. 1998;134(9):1162. doi:

We read with great interest the article by Memar et al1 reporting the presence of human herpesvirus 8 (HHV-8) DNA in tissue samples of 4 of 6 pemphigus vulgaris and in all 6 pemphigus foliaceus lesions. We performed a similar study analyzing 15 formalin-fixed, paraffin-embedded skin lesions from 12 patients with pemphigus vulgaris and 2 patients with pemphigus foliaceus. We tested for HHV-8 DNA using a nested polymerase chain reaction assay, with oligonucleotide primers of the ORF26 gene region.2 In addition, the presence of appropriate DNA was verified in all samples by testing for the human β-globin gene. We were unable to detect HHV-8 DNA in any of the 15 tissue specimens analyzed, although we have previously shown that this assay detects HHV-8 DNA in all Kaposi sarcoma biopsy samples tested.2

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