Idiopathic hyperandrogenism is a common disorder that may result in acne in women. Spironolactone is frequently used to treat disorders involving an excess of androgen production. Several researchers have reported different adverse effects with variable regimens of spironolactone treatment. In our study, 38 women with acne were treated with spironolactone, 50 mg twice daily, on days 5 through 21 of their menstrual cycle and were followed up prospectively for adverse effects and improvement in their acne.
Lubbos HG, Hasinski S, Rose LI, Pollock J, Spielvogel RL. Adverse Effects of Spironolactone Therapy in Women With Acne. Arch Dermatol. 1998;134(9):1162-1163. doi: