[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.157.19.94. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Correspondence
September 1998

Alopecia Areata Has Low Plasma Levels of the Vasodilator/Immunomodulator Calcitonin Gene–Related Peptide

Arch Dermatol. 1998;134(9):1164-1165. doi:

The etiology of alopecia areata (AA) is unknown, but it is presumed to result from an autoimmune reaction. Thyroid abnormalities are increased in AA, but levothyroxine sodium replacement therapy does not induce hair regrowth.1 Calcitonin gene–related peptide (CGRP) is a 37–amino acid peptide produced by thyroid C cells. Calcitonin gene–related peptide is the most powerful cutaneous vasodilator known and is present in peripheral sensory nerves, the central nervous system, splanchnic organs, and around eccrine glands.2 Calcitonin gene–related peptide preferentially vasodilates the head, neck, upper part of the trunk, and upper arms.

First Page Preview View Large
First page PDF preview
First page PDF preview
×