We read with interest the article by Meadows et al1 in a recent issue of the ARCHIVES on the treatment of molluscum contagiosum with cidofovir. In 1 of the patients in their report, cidofovir was compounded as a 3% cream in a combination vehicle. We report a novel application of cidofovir in a child with the acquired immunodeficiency syndrome (AIDS) with cutaneous herpes simplex virus (HSV) infection. Using a 1% topical cidofovir cream, we observed successful reepithelialization of a facial ulcer caused by acyclovir-resistant, foscarnet-unresponsive HSV.
Lateef F, Don PC, Kaufmann M, White SM, Weinberg JM. Treatment of Acyclovir-Resistant, Foscarnet-Unresponsive HSV Infection With Topical Cidofovir in a Child With AIDS. Arch Dermatol. 1998;134(9):1169-1170. doi: