[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
October 1998

Follow-up of Patients With Axillary Hyperhidrosis After Botulinum Toxin Injection

Arch Dermatol. 1998;134(10):1298-1299. doi:

We read with interest the article by Naumann et al1 on botulinum toxin therapy for focal hyperhidrosis and would like to contribute our own findings regarding the long-term efficacy of botulinum toxin therapy, as well as the putative effects on apoeccrine secretion. After our initial reports on the efficacy of high-dose (500 U per axilla) botulinum toxin A (Dysport, Ipsen Biotech, Paris, France) in a series of selected patients with severe axillary2 and compensatory3 hyperhidrosis (sweat secretion up to 800 mg/min), we recently conducted a 1-year follow-up (M.H., S. Breit, MD, A. C-B., and G.P., unpublished data, May 1998). Nine of 12 patients were still satisfied with sweat control that was consistently below 100 mg/min measured using gravimetry on several occasions. Three patients showed mitigated recurrence of axillary hyperhidrosis after 3, 4, and 7 months, respectively, which could be overcome by a second injection of botulinum toxin A with lasting efficacy. It should be noted that at present 2 preparations of botulinum toxin A are commercially available (Botox, Allergan, Irvine, Calif, and Dysport, Ipsen Biotech), which have to be distinguished regarding their respective dosage.

First Page Preview View Large
First page PDF preview
First page PDF preview