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Citations 0
Correspondence
November 1998

Questions About Study of Cultured Skin Equivalent for Venous Ulcers

Arch Dermatol. 1998;134(11):1483. doi:

Falanga and coworkers1 in the March ARCHIVES describe a new treatment of venous ulcers using a bilayered, artificial skin equivalent containing both epidermal and dermal components. The unique feature is that both components contain living human cells: an epidermal layer of cultured living human keratinocytes and a dermal layer with living human dermal fibroblasts. Because many variables influence the rate of venous ulcer healing, a new treatment must be compared with a suitable control. And since the unique feature of this dressing is the presence of 2 types of living human cells, the logical control would have been the same dressing with dead cells. This dead-cell dressing could be accomplished by gamma radiation without visible change to the human skin equivalent. In this way, a truly double-blind, properly controlled study could have been carried out.

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