In the dermis, there was a nodule composed of sheets of polygonal cells with vesicular nuclei, prominent nucleoli, frequent mitoses, and small amounts of lightly eosinophilic cytoplasm surrounded by a dense lymphocytic infiltrate. The tumor was nonencapsulated and was not connected to the epidermis Adnexal structures, blood vessels, and nerves were not involved. The tumor stained strongly for cytokeratin and weakly for epithelial membrane antigen. More than 50% of the cells in the lymphocytic infiltrate were positive for the pan–T-cell marker CD3, and about 10% were positive for the B-cell marker CD20. The patient did well postoperatively and is without recurrence to date.
Enlarging Facial Nodule on an Elderly Patient. Arch Dermatol. 1998;134(12):1627-1632. doi: