Years ago Buckminster Fuller, the world-renowned architect and engineer, walked into our office with 3 mason jars full of old batteries that he had collected for years from his hearing aid. He wanted us to study what role the batteries might be playing in his dermatitis. It was an awesome assignment from one of the world's greatest minds. Here was the man who invented the geodesic dome, a man who anticipated the cagelike architecture of a whole class of molecules now known as fullerenes. We never discovered the role his batteries may have played in his dermatitis, but we did hear loud and clear his call for clinical research.
Shelley WB. A Plea for Clinical Research. Arch Dermatol. 2000;136(1):88-89. doi:10.1001/archderm.136.1.88