To paraphrase Charles Dickens, the new millennium appears to be the spring of hope and the winter of despair for academic dermatology.
For centuries, dermatologic disease was grouped into arcane classifications that depend on clinical presentation alone. Then, primarily in the 20th century, histopathology was added to help sort out similar-appearing skin diseases. By the end of the 20th century, we have begun to understand the pathophysiology of many diseases through basic research. Newly developed pharmaceuticals have allowed us to treat previously untreatable and even fatal skin diseases. Currently, the revolution in molecular biology has resulted in an explosion of knowledge about previously obscure genetic skin diseases. Therefore, as we enter the new millennium, we have great reason for hope.
Stanley JR. Risk for the New MillenniumRegulation Gone Berserk. Arch Dermatol. 2000;136(1):92-93. doi:10.1001/archderm.136.1.92