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January 2000

Elevated RANTES Levels in Plasma or Skin and Decreased Plasma IL-10 Levels in Subsets of Patients With Severe Atopic Dermatitis

Arch Dermatol. 2000;136(1):125-126. doi:

Regulated on activation, normal T-cell–expressed and secreted chemokine (RANTES) is a β (C-C) chemokine released by T lymphocytes, other inflammatory cells, and platelets and plays an important role in allergic inflammatory processes. In this study, levels of RANTES, another platelet-derived chemokine (β-thromboglobulin [β-TG]), IFN-γ, IL-2, IL-4, IL-5, and IL-10 were measured in plasma in 197 patients with atopic dermatitis (AD) who were not taking glucocorticoids and/or immunosuppressing drugs for more than 3 months before the study. In 20 of these patients, skin RANTES content was measured. The extent of AD was classified as severe, moderate, or mild according to the surface area involved with dermatitis, as outlined by Horigoe and Hanada.1

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