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January 2000

Chronic Progressive Ocular Cicatrization

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Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Dermatol. 2000;136(1):113-118. doi:

Sections demonstrated scant inflammation consisting of lymphocytes, plasma cells, and rare eosinophils with mild fibrosis. There was no evidence of bullae. These findings were not diagnostic of a primary immunobullous disease.

Ocular cicatricial pemphigoid is a chronic progressive autoimmune disease that leads to scarring of the conjunctiva in approximately 70% of patients, and may eventually lead to blindness.1 Early changes may show unilateral or bilateral nonspecific conjunctivitis.2 Progression of the disease leads to scarring of the conjunctiva, with fibrosis beneath the conjunctival epithelium and subsequent formation of symblepharon (adhesion of palpebral and bulbar conjunctiva), ankyloblepharon (fusion of eyelids), entropion, and trichiasis (ingrowing eyelashes).3 Late changes include keratinization of the epithelium of the ocular surface and corneal opacity.3

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