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February 2000

Systemic Photodynamic Therapy Is a Safe and Effective Treatment for Psoriasis

Arch Dermatol. 2000;136(2):271-272. doi:

Oral administration of 8-methoxypsoralen and irradiation with UV-A radiation (PUVA) is a well-established treatment regimen for psoriasis.1 Evidence for an increased risk of malignant melanoma in PUVA-treated patients2 prompted a dialogue as to whether PUVA should be abandoned for this indication.3 Photodynamic therapy (PDT) encompasses the therapeutic use of photochemical reactions mediated through the interaction of light, photosensitizing drugs, and oxygen. Demonstration of therapeutic efficacy using a polychromatic light source was an important step toward clinical application of PDT in the treatment of psoriasis.4

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