The biopsy specimen showed necrosis of the dermis and the subcutaneous fat, with narrowing or occlusion of the arterioles from medial calcification, intimal fibrosis, and thrombi of calcium, with no evidence of vasculitis or panniculitis. A von Kossa stain for calcium deposits was positive.
Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification. Calciphylaxis is most commonly seen in patients with end-stage renal disease and hyperparathyroidism. Since dialysis has become a common practice, calciphylaxis has become even rarer. To the best of our knowledge, this is the third reported case of penile necrosis due to calciphylaxis.1,2
Penile Necrosis. Arch Dermatol. 2000;136(2):259-264. doi: