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Evidence-Based Dermatology: Abstract
March 2000

A Systematic Review of the Treatment of Scabies

Arch Dermatol. 2000;136(3):387-389. doi:10.1001/archderm.136.3.387

Interventions for treating scabiesWalker GJA, Johnstone PW Cochrane Review. Available at: http://www.update-software.com/abstracts/ab000320.htm. Accessibility verified January 5, 2000.

Walker and Johnstone performed a systematic review to assess the effectiveness and safety of topical and systemic drug treatments for scabies. The Cochrane Library extended search strategy for identifying trials was used to search the Cochrane Infectious Diseases Group trial registry, the Cochrane Controlled Clinical Trials Registry, MEDLINE, Embase, military records, traditional medicine databases, and contacting international specialist centers and drug manufacturers. Randomized trials of any drug treatment for scabies were selected for review. The diagnostic criteria for scabies of the included studies varied from clinical diagnosis (based on history, sites of lesions, and the presence of typical burrows) to visualizing mites extracted from burrows or microscopic confirmation demonstrating mites, ova, or scabala. The authors assessed the quality of trials on the basis of the adequacy of concealment of allocation, generation of allocation sequence, use of intent-to-treat analysis, and degree of blinding. Observational studies were included for toxic effects and tolerability assessment, but they were not systematically reviewed.

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