We read with interest the article in the ARCHIVES titled "Altered Lamellar Body Secretion and Stratum Corneum Membrane Structure in Netherton Syndrome," by Fartasch et al.1 Especially of interest was their finding that premature lamellar body secretion and foci of electron-dense material in the intercellular spaces of the stratum corneum seem to be frequent and relatively specific markers for Netherton syndrome (NS). The authors comment that these ultrastructural features diagnosed on skin biopsy specimens from erythrodermic patients could hasten the diagnosis of NS.
Powell J. Increasing the Likelihood of Early Diagnosis of Netherton Syndrome by Simple Examination of Eyebrow Hairs. Arch Dermatol. 2000;136(3):423-424. doi: