Androgens have been implicated in setting the capacity for perspiration. However, a role of androgen excess in inordinate sweating has not been previously noted. We report the case of a girl who developed hyperhidrosis during puberty in association with the hyperandrogenism of polycystic ovary syndrome.
A 15½-year-old girl presented with axillary hyperhidrosis of 1 year's duration. The sweating ceased when she was asleep, but was constant during the day and unrelieved by desiccants, requiring her to change shirts about 4 times a day. Pubarche occurred at age 10 years, thelarche at age 11 years, and menarche at age 12 years. Menses were normal. Her father had adult-type diabetes mellitus. Findings on examination were profuse hyperhidrosis (Figure 1) in a nonobese sexually mature girl (body mass index [BMI], calculated as the weight in kilograms divided by the square of the height in meters: weight [kg]/[height (m)]2, 22.8), without acne, hirsutism (Ferriman-Gallway score, 6; normal adult, <8), alopecia, or acanthosis nigricans.
Kim SS, Rosenfield RL. Hyperhidrosis as the Only Manifestation of Hyperandrogenism in an Adolescent Girl. Arch Dermatol. 2000;136(3):430-431. doi: