A 47-year-old woman presented with a 19-year history of Crohn disease, complicated by ileocolitis, fistulous tract formation, and multiple cutaneous manifestations, including nonfistulous erosions, ulcerations, and nodules involving her perineum and inner thighs. Her clinical course included several surgical reconstructive procedures, azathioprine therapy (100-300 mg/d orally for over 5 years), and long-term courses of intravenous methylprednisolone and oral prednisone (up to 100 mg/d), ciprofloxacin, and metronidazole. All of these therapeutic interventions failed to achieve complete and prolonged remission of her intestinal and cutaneous disease.
Geyer AS, Anhalt GJ, Nousari HC. Effectiveness of Infliximab in the Treatment of Refractory Perineal Cutaneous Crohn Disease. Arch Dermatol. 2000;136(4):459-460. doi:10.1001/archderm.136.4.459