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April 2000

A Controlled Trial, LSE vs Killed LSE, Is Needed

Arch Dermatol. 2000;136(4):555. doi:

Muhart el al,1 in their August ARCHIVES study on living skin equivalent (LSE) treatment of split-thickness donor sites, established that LSE is a well-tolerated, albeit expensive ($140 per square inch), wound dressing. That is all. Their speculation that "LSE behaves like autograft" and might provide an "off the shelf" substitute for a skin graft1 ignores fundamental differences in healing between partial- and full-thickness skin wounds. Partial-thickness wounds heal rapidly as a result of reepithelization from adnexal tissue in the wound base. Full-thickness wounds heal slowly and do not reepithelize from their base; that is why skin grafts are employed as cover.

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