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April 2000

Lack of Hypocomplementemia in Chronic Urticaria

Arch Dermatol. 2000;136(4):558-559. doi:

Chronic urticaria (CU) is a frequent and disabling disease. In most cases, no etiologic factor or pathophysiologic mechanism can be found. The role of the complement system in the pathogenesis of urticaria has often been examined.13 Moreover, it was demonstrated recently that autoantibodies against the high-affinity IgE receptor (anti-FcϵRIa antibodies) implicated in CU belong to the complement-fixing isotypes.4

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