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May 2000

Simultaneous Infection by Human Herpesvirus 7 and Human Parvovirus B19 in Papular-Purpuric Gloves-and-Socks Syndrome

Arch Dermatol. 2000;136(5):672-673. doi:

We read with great interest the article by Ruzicka et al1 on the possible role of human herpesvirus (HHV) 6 in the etiology of papular-purpuric gloves-and-socks syndrome (PPGSS). This is a newly recognized dermatosis. Nearly 30 cases have been described in the European literature1 and already 2 documented cases in the United States.2 As possible causative agents, either human parvovirus (HPV) B19 (in half of the cases)24 or measles virus, cytomegalovirus, Coxsackievirus B6, hepatitis B virus,5 or no viral cause has been reported in individual cases based on serological evidence.

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