We read with great interest the article by Ruzicka et al1 on the possible role of human herpesvirus (HHV) 6 in the etiology of papular-purpuric gloves-and-socks syndrome (PPGSS). This is a newly recognized dermatosis. Nearly 30 cases have been described in the European literature1 and already 2 documented cases in the United States.2 As possible causative agents, either human parvovirus (HPV) B19 (in half of the cases)2- 4 or measles virus, cytomegalovirus, Coxsackievirus B6, hepatitis B virus,5 or no viral cause has been reported in individual cases based on serological evidence.
Ongrádi J, Becker K, Horváth A, Hidvégi E, Mezey I. Simultaneous Infection by Human Herpesvirus 7 and Human Parvovirus B19 in Papular-Purpuric Gloves-and-Socks Syndrome. Arch Dermatol. 2000;136(5):672-673. doi: