Wound healing is a complex biological process. The imbalance in growth factors, cytokines, and matrix metalloproteinases in wounds promotes the establishment and maintenance of chronic wounds. We are introducing a new method for the treatment of chronic wounds using allogenic keratinocytes suspended in human fibrin glue for the stimulation of granulation and reepithelialization.
We describe a 76-year-old woman with an arteriovenous ulcer extending to the entire lower leg. Surgical treatment with a femoropopliteal bypass improved the arterial situation but showed no effect on wound healing. Despite intensive wound care, including surgical and enzymatic debridement, hydrocolloid dressings, and compression therapy, there was no development of fresh granulation tissue and no tendency of reepithelialization within 1 year (Figure 1).
Siedler S, Schuller-Petrovic S. Allogenic Keratinocytes Suspended in Human Fibrin Glue Used for Wound Healing Support in Chronic Leg Ulcers. Arch Dermatol. 2000;136(5):676-678. doi: