Microscopic examination of the punch biopsy specimen revealed orthokeratotic hyperkeratosis and slight acanthosis of the epidermis. The granular layer was unaffected. A very sparse superficial perivascular lymphocytic infiltrate was present.
Our patient was initially given 10% salicylic acid ointment and 10% urea cream, but his condition did not improve.
The term erythrokeratodermia denotes the association of hyperkeratosis and erythema in persistent, although sometimes varying, circumscribed lesions. A few distinct syndromes have been described thus far.
Generalized Erythematous Plaques. Arch Dermatol. 2000;136(5):665-670. doi: