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Off-Center Fold
May 2000

Generalized Erythematous Plaques

Author Affiliations


Arch Dermatol. 2000;136(5):665-670. doi:

Microscopic examination of the punch biopsy specimen revealed orthokeratotic hyperkeratosis and slight acanthosis of the epidermis. The granular layer was unaffected. A very sparse superficial perivascular lymphocytic infiltrate was present.

Our patient was initially given 10% salicylic acid ointment and 10% urea cream, but his condition did not improve.

The term erythrokeratodermia denotes the association of hyperkeratosis and erythema in persistent, although sometimes varying, circumscribed lesions. A few distinct syndromes have been described thus far.

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