Prurigo nodularis (PN) is a disease characterized by chronic, intense, itchy nodules in the distal extremities of the limbs.1,2 Although topical steroids have been widely used to treat PN, there have been no controlled trials evaluating their efficacy. Topical vitamin D3 (tacalcitol) has been reported effective for PN in an open study,3 but our preliminary report is the first prospective, randomized, double-blind, right/left comparative study evaluating the therapeutic efficacy and tolerability of 50 µg/g calcipotriol ointment (Leo Pharmaceutical Products, Ballerup, Denmark) with that of 0.1% betamethasone valerate ointment in the treatment of PN.
Wong S, Goh CL. Double-blind, Right/Left Comparison of Calcipotriol Ointment and Betamethasone Ointment in the Treatment of Prurigo Nodularis. Arch Dermatol. 2000;136(6):807-808. doi: