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August 2000

Cutaneous γδ T-Cell Lymphomas—How and Why Should They Be Recognized?

Arch Dermatol. 2000;136(8):1052-1054. doi:10.1001/archderm.136.8.1052

IN THIS issue of the ARCHIVES, Toro and coworkers1 report the clinicopathologic features of 3 adult male patients with cutaneous γδ T-cell lymphomas (CTCLs) involving the skin. These patients were distinguished by multiple plaques, tumors, and subcutaneous nodules distributed over their extremities. The lesions showed histologic evidence of epidermotropism, dermal and subcutaneous infiltration by atypical lymphocytes without cerebriform nuclei. The tumor cells had a distinct immunophenotype expressing the γδ T-cell receptor (TCR) heterodimer instead of the more common αβ TCR heterodimer. In addition, the tumor cells had a cytotoxic profile, expressing T-cell intracellular antigen 1 (TIA-1), granzyme B, and perforin. Importantly, all 3 patients with γδ CTCL had an aggressive clinical course with resistance to various chemotherapies. Similar results have been reported in the literature for patients with this uncommon type of lymphoma.25

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