Evidence-Based Dermatology: Research Commentary
September 2000

Reactivation of Genital Herpes Simplex Virus 2 Infection in Asymptomatic Seropositive Persons Is Frequent

Author Affiliations

DamianoAbeniMD, MPHMichaelBigbyMDPaoloPasquiniMD, MPHMoysesSzkloMD, MPH, DrPHHywelWilliamsMSc, PhD, FRCP


Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Dermatol. 2000;136(9):1141-1142. doi:10.1001/archderm.136.9.1141

Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive personsWald A, Zeh J, Selke S, Warren T, Ryncarz AJ, Ashley R, Krieger JN, Corey LN Engl J Med. 2000;342:844-850

Roughly 25% of adults in the United States are estimated to be herpes simplex virus 2 (HSV-2) seropositive, but only 10% to 25% of HSV-2–seropositive individuals have a known history of recognized genital lesions. It has been generally assumed that asymptomatic HSV-2–seropositive individuals not only have less frequent and less severe recurrences but also are less likely to have asymptomatic viral shedding. Two observations, however, suggest evidence contrary to this belief. First, HSV-2–seropositive individuals who do not have a history of genital lesions do notice that they have recurrent episodes once they are educated about the clinical signs and symptoms of HSV infections. Second, most HSV-2 infections are acquired from partners who lack a history of genital HSV infection.

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