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Evidence-Based Dermatology: Research Commentary
September 2000

Pentoxifylline in the Treatment of Venous Leg Ulcers

Author Affiliations
 

DamianoAbeniMD, MPHMichaelBigbyMDPaoloPasquiniMD, MPHMoysesSzkloMD, MPH, DrPHHywelWilliamsMSc, PhD, FRCP

Arch Dermatol. 2000;136(9):1142-1143. doi:10.1001/archderm.136.9.1142

Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcersDale JJ, Ruckley CV, Harper DR, Gibson B, Nelson EA, Prescott RJBMJ. 1999;319:875-878.

The objective of this study was to determine if pentoxifylline, 400 mg, taken orally 3 times a day as an adjunct therapy to ambulatory limb compression bandages to treat venous leg ulcer was more efficacious than ambulatory limb compression bandages with a matching placebo by 24 weeks of care. Previous clinical trials had produced conflicting results.

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